Endocrine Abstracts

Objective: Thyroid peroxidase antibody (TPOAb) positivity is the most important risk factor for overt/subclinical hypothyroidism and partly guides levothyroxine treatment indications during pregnancy. TPOAb positivity is usually defined by manufacturer cutoffs which are typically derived in non-pregnant populations with concentrations ≥95th percentile. Besides the general lack of assay uniformity, current TPOAb positivity cutoffs are likely to underestimate gestational t...